Found an animal study? Here's the translation formula from animal to human dosage PDF Print E-mail
wss_news_animal_supplement_doses.jpg As new drugs or herbal supplements are developed, it is essential to appropriately translate the drug dosage from one animal species to another. The animal dose should not be extrapolated to a human equivalent dose (HED) by a simple conversion based on body weight, as was reported. For the more appropriate conversion of drug doses from animal studies to human studies, researchers of University of Wisconsin suggest using the body surface area (BSA) normalization method. BSA correlates well across several mammalian species with several parameters of biology, including oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function. Formula for dose translation based on BSA: HED (mg/kg) = Animal does (mg/g) multiplied by (Animal Km divided by Human Km)
Species Weight (kg) BSA (m2) Km factor
Human (adult) 60 1,6 37
Rat 0,15 0,025 6
Mouse 0,02 0,007 3
Guinea pig 0,4 0,05 8
Rabbit 1,8 0,15 12
Monkey 3 0,24 12
Dog 10 0,5 20

So if it's a study that used rat, you have to take the dose used in mg/kg/day –and first multiply it by 6 and then divide the result by 37. Complete study: FASEB J. 2008 Mar;22(3):659-61. Epub 2007 Oct 17.
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